國立臺灣大學醫學院牙醫學系School of Dentistry College of Medicine National Taiwan University
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郭生興 教授

電話:23123456 ext 67405
Email:shkok@ntu.edu.tw


學經歷

國立台灣大學牙醫學系學士,民國72年
國立台灣大學臨床牙醫學研究所博士,民國92年

國立台灣大學口腔顎面外科專科醫師,民國78年
國立臺灣大學牙醫學系副教授,民國92年
臺大醫院口腔顎面外科主任,民國96年

專長

  1. 口腔顎面外科學
  2. 人工牙根種植手術
  3. 顎骨及牙床矯正手術

主要研究領域

  1. 口腔癌之致病機轉及治療:
    利用分子生物學技術研究口腔癌中癌基因、抑癌基因及其他基因標的之變化,配合臨床資料,建立台灣口腔癌分子流行病學資料。根據上述資訊,研訂合理之口腔癌預防及治療方針。
  2. 口腔植體學:
    各種牙科植體之生物反應及臨床應用,各種骨種植技術在植體手術中之效果。
  3. 正顎手術:
    各種正顎手術方法之臨床效益,特別是手術造成之顏面軟組織變化。

研究著作選列

     
  1. Hou KL, Lin SK, Chao LH, Hsiang-Hua Lai E, Chang CC, Shun CT, Lu WY, Wang JH, Hsiao M, Hong CY and Kok SH (2017). Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption. Biofactors 43: 170-180. (SCI)
  2. Kok SH, Hou KL, Hong CY, Chao LH, Lai EH, Wang HW, Yang H, Shun CT, Wang JS, Lin SK (2015). Sirtuin 6 modulates hypoxia-induced apoptosis in osteoblasts via inhibition of glycolysis: implication for pathogenesis of periapical lesions. Journal of Endodontics 41(10):1631-7. (SCI)
  3. Ko HH, Lee JJ, Chen HM, Kok SH, Kuo MYP, Cheng SJ, Chiang CP (2015). Upregulation of vascular endothelial growth factor mRNA level is significantly related to progression and prognosis of oral squamous cell carcinomas. Journal of the Formosan Medical Association 114:605-611. (SCI)
  4. Ho Y, Kok SH, Wang JS and Lin LD (2014). Translucent titanium coating altered the composition of focal adhesions and promoted migration of osteoblast-like MG-63 cells on glass. Journal of Biomedical Materials Research Part A 102: 1187-1201. (SCI)
  5. Chen MH, Chang JZC, Kok SH, Chen YJ, Huang YD, Cheng KY and Lin CP (2014). Intraobserver reliability of landmark identification in cone-beam computed tomography-synthesized two-dimensional cephalograms versus conventional cephalometric radiography: A preliminary study. Journal of Dental Sciences 9: 56-62. (SCI)
  6. Lee JJ, Cheng SJ, Wang YP, Jeng JH, Chiang CP, Kok SH(2013). Osteonecrosis of the jaws associated with the use of yearly zoledronic acid: Report of 2 cases. Head and Neck-Journal for The Sciences and Specialties of The Head and Neck 35(1):E6-10. doi: 10.1002/hed.21758. (SCI)
  7. Kok SH, Lin LD, Hou KL, Hong CY, Chang CC, Hsiao M, Wang JH, Lai EH, Lin SK (2013). Simvastatin inhibits Cyr61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of SIRT1/FoxO3a signaling. Arthritis and Rheumatism 65(3):639-49. (SCI)
  8. Cheng SJ, Lee JJ, Cheng SL, Chen HM, Chang HH, Wang YP, Kok SH, Kuo MYP, Chiang CP (2012). Increased serum placenta growth factor level is significantly associated with progression, recurrence and poor prognosis of oral squamous cell carcinoma. Oral Oncology 48(5):424-28. (SCI)
  9. Ho Y, Kok SH, Wang JS, Lin LD (2012). Translucent Titanium Coating Facilitates Observation of Osteoblast Migration Behavior on a Titanium Surface. International Journal of Oral & Maxillofacial Implants 27(2):278-87. (SCI)
  10. Kok SHKSH, Hou KL, Hong CY, Wang JS, Liang PC, Chang CC, Hsiao M, Yang HA, Lai EHH, Lin SK (2011). Simvastatin Inhibits Cytokine-Stimulated Cyr61 Expression in Osteoblastic Cells A Therapeutic Benefit for Arthritis. Arthritis and Rheumatism 63(4):1010-20. (SCI)

 

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