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Jenny Zwei-Chieng Chang Associate Professor

Tel:886-2-23123456 ext 62347


DDS, National Taiwan University, 1994
MS, National Taiwan University, 2004
PhD, National Taiwan University, 2013

Professional specialties

Orthodontic and Dentofacial

Main Research Interests

  • Conventional roentgenographic cephalometric analysis appears to have certain limitations. Measurement of lines and angles by traditional methods is not able to locate the actual sites where the growth or treatment changes have occurred within the craniofacial skeleton. The conventional metrical approach depends upon reference planes and points. If the registration points or planes vary greatly, the use of such a technique may lead to misdiagnosis or misinterpretation.
  • Recently, geometric morphometric methods for shape comparisons have been developed to measure the biological size and shape changes induced by growth and treatment. Approaches such as thin-plate spline analysis, Euclidean distance matrix analysis, finite element analysis, tensor analysis, Fourier analysis, and shape-coordinate analysis were introduced as methodological enhancements in morphometrics. These methods are preferable to conventional cephalometry in that they provide explanatory visualization of shape changes and highlight regions of localized dissimilarity.
  • Our recent studies focus on the use of average geometries, generated by means of Procrustes analysis and in combination with graphical analysis, utilizing thin-plate spline interpolation and strain tensor methods to localize craniofacial changes in shape and size during growth and/or after orthodontic/orthopedic treatment. Maximum and minimum principal extensions were drawn to express the directions of shape change.

Selected Publications

  1. Chang JZC, Hsieh YP, Lin WH, Chen HM and Kuo MYP (2017). Activation of transforming growth factor-1 by thrombin via integrins v1, v3, and v5 in buccal fibroblasts: Suppression by epigallocatechin-3-gallate. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 39: 1436-1445. (SCI)
  2. Hou KL, Lin SK, Kok SH, Wang HW, Lai EHH, Hong CY, Yang H, Wang JS, Lin LD and Chang JZC (2017). Increased Expression of Glutaminase in Osteoblasts Promotes Macrophage Recruitment in Periapical Lesions. Journal of Endodontics 43: 602-608. (SCI)
  3. Yeh CC, Chang JZC, Yang WH, Chang HH, Lai EHH, Kuo MYP (2015). NADPH oxidase 4 is involved in the triethylene glycol dimethacrylate-induced reactive oxygen species and apoptosis in human embryonic palatal mesenchymal and dental pulp cells. Clinical Oral Investigations 19(6):1463-71.(SCI)
  4. Liu PH, Lai EHH, Yang H and Chang JZC (2015). Orthodontic treatment of a complete transposed impacted maxillary canine. Journal of Dental Sciences 10: 102-108. (SCI)
  5. Chen MH, Chang JZC, Kok SH, Chen YJ, Huang YD, Cheng KY and Lin CP (2014). Intraobserver reliability of landmark identification in cone-beam computed tomography-synthesized two-dimensional cephalograms versus conventional cephalometric radiography: A preliminary study. Journal of Dental Sciences 9: 56-62. (SCI)
  6. Chang JZC, Yang WH, Deng YT, Chen HM, Kuo MYP (2013). EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts. Clinical Oral Invegations 17(2):455-61.
  7. Chang JZC, Yang WH, Deng YT, Chen HM, Kuo MYP (2012). Thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production in human buccal mucosal fibroblasts: Inhibition by epigallocatechin-3-gallate. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 34(8):1089-94. (SCI)
  8. Chang JZ-C, Chen Y-J, Tung Y-Y, Chiang Y-Y, Lai EH-H, Chen W-P, Lin C-P (2012). Effects of thread depth, taper shape, and taper length on the mechanical properties of mini-implants. American Journal of Orthodontics and Dentofacial Orthopedics 141(3):279-88. (SCI)
  9. Chang JZC, Hu FC, Lai EHH, Yao CC, Chen MH, Chen YJ (2011). Landmark identification errors on cone-beam computed tomography-derived cephalograms and conventional digital cephalograms. American Journal of Orthodontics and Dentofacial Orthopedics 140:e289-e297. (SCI)
  10. Chang JZC, Liu PH, Wang YT, Chen YJ, Yao CC, Lai EHH (2011). Orthodontic-prosthetic implant anchorage in a partially edentulous patient. Journal of Dental Sciences, 6:176-180. (SCI)

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